Investigating genetic causes of spinal abnormalities using dogs
Novel Genetic Models for Vertebral Abnormalities
This study is looking at the genetic causes of spinal problems like scoliosis by studying dogs, and it aims to help us understand these issues better so we can improve diagnosis and treatment for everyone affected.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Purdue University NIH-funded |
| Lab location | 1 site (West Lafayette, United States) |
| Project ID | NIH-10530583 on NIH RePORTER |
What this research studies
This research focuses on identifying genetic factors that contribute to spinal abnormalities, particularly idiopathic scoliosis, by using dogs as a model organism. The principal investigator, Dr. Kari Ekenstedt, is working under the mentorship of experienced researchers in comparative medical genetics. The project aims to uncover susceptibility genes and enhance understanding of spinal disorders, which could lead to better diagnostic and therapeutic strategies. The research will also involve training in advanced techniques and grant writing to support future studies.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with a family history of spinal abnormalities or those diagnosed with idiopathic scoliosis.
Not a fit: Patients with spinal abnormalities unrelated to genetic factors or those with conditions not studied in this research may not receive benefit.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for spinal abnormalities in both dogs and humans.
How similar studies have performed: Previous research using animal models to study genetic causes of spinal disorders has shown promise, indicating that this approach could yield valuable insights.
Where this research is happening
West Lafayette, United States
- Purdue University — West Lafayette, United States (Active)
Researchers
- Principal investigator: Ekenstedt, Kari J — Purdue University
- Study coordinator: Ekenstedt, Kari J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.