Investigating genetic and therapeutic methods to improve recovery from severe shoulder injuries.
Genetic and Therapeutic Approaches to Alleviate the Pathology of Massive Rotator Cuff Tears
['FUNDING_R21'] · DUKE UNIVERSITY · NIH-11126625
This study is looking at how certain cells in your shoulder muscles behave after a big rotator cuff tear, which can make recovery harder, and it aims to find new ways to help people heal better from these injuries.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DUKE UNIVERSITY (nih funded) |
| Locations | 1 site (DURHAM, UNITED STATES) |
| Trial ID | NIH-11126625 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the biological mechanisms behind massive rotator cuff tears, which are common and debilitating shoulder injuries. It aims to explore how certain cells in the muscle contribute to fat accumulation and fibrosis after injury, which can hinder recovery. By using advanced techniques such as genetic tracing and RNA sequencing in animal models, the researchers hope to identify key molecular signals that could lead to better therapeutic strategies for patients suffering from these injuries.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced massive rotator cuff tears and are seeking innovative treatment options.
Not a fit: Patients with minor shoulder injuries or those who do not have rotator cuff tears may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that enhance recovery and reduce the risk of re-injury for patients with rotator cuff tears.
How similar studies have performed: Previous research has shown promise in understanding muscle pathology related to rotator cuff injuries, suggesting that this approach could yield valuable insights.
Where this research is happening
DURHAM, UNITED STATES
- DUKE UNIVERSITY — DURHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HILTON, MATTHEW J. — DUKE UNIVERSITY
- Study coordinator: HILTON, MATTHEW J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.