Investigating genetic and microbial factors that affect the severity of Atopic Dermatitis.
Genetic and microbial modifiers of Atopic Dermatitis (AD): Mechanisms of increased AD severity in patients with the R576 polymorphism in IL-4Ra and impact of S aureus skin decolonization on AD
This study is looking at how certain genes and skin bacteria might affect how bad Atopic Dermatitis (AD) can get, and it's for people of all ages who have this condition.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11066508 on NIH RePORTER |
What this research studies
This research explores how specific genetic variations and the presence of certain bacteria on the skin can influence the severity of Atopic Dermatitis (AD). The team of experienced researchers will analyze patients with a particular genetic marker (R576 polymorphism in IL-4Ra) and assess the effects of decolonizing Staphylococcus aureus bacteria from the skin. By recruiting participants from various clinics, they aim to gather comprehensive data on both pediatric and adult populations. The study employs advanced clinical and laboratory techniques to better understand the mechanisms behind AD and improve treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Atopic Dermatitis, particularly those with the R576 polymorphism in IL-4Ra.
Not a fit: Patients without Atopic Dermatitis or those not carrying the specific genetic marker may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients suffering from Atopic Dermatitis by targeting genetic and microbial factors.
How similar studies have performed: Previous research has shown promising results in understanding the role of genetics and microbial factors in allergic diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Geha, Raif Salim — Boston Children's Hospital
- Study coordinator: Geha, Raif Salim
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.