Investigating genetic and metabolic factors in diabetes health disparities
Genome, Metabolome, Ancestry and Diabetes Health Disparity
This study is looking at how genes and metabolism affect type 2 diabetes and heart issues, especially in South Asian communities, to find better ways to prevent and treat diabetes for everyone.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Oklahoma Hlth Sciences Ctr NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project ID | NIH-10468147 on NIH RePORTER |
What this research studies
This research focuses on understanding the genetic and metabolic factors that contribute to type 2 diabetes (T2D) and related cardiovascular complications, particularly in underserved populations such as South Asians. By utilizing advanced genome and metabolome analysis techniques, the study aims to identify unique genetic markers and metabolites that may influence the risk of T2D. The research will involve collecting biological samples and health data from participants to explore how these factors vary among different ethnic groups. Ultimately, the goal is to enhance precision medicine approaches for diabetes treatment and prevention.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals of South Asian descent who are at risk for or have been diagnosed with type 2 diabetes.
Not a fit: Patients who do not belong to the South Asian ethnic group or those without a predisposition to type 2 diabetes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatment strategies for diabetes, particularly for populations at higher risk.
How similar studies have performed: While similar genome-metabolome studies have shown success in European populations, this research represents a novel approach in the South Asian demographic.
Where this research is happening
Oklahoma City, United States
- University of Oklahoma Hlth Sciences Ctr — Oklahoma City, United States (Active)
Researchers
- Principal investigator: Sanghera, Dharambir K. — University of Oklahoma Hlth Sciences Ctr
- Study coordinator: Sanghera, Dharambir K.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.