Investigating genetic and immune factors in triple negative breast cancer
Prediagnostic exposures, germline genetics, and triple negative breast cancer mutational and immune profiles
This study is looking at the genes and immune responses in triple negative breast cancer to find out what makes it different from other types, with the hope of discovering better, personalized treatments for patients like you.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11060923 on NIH RePORTER |
What this research studies
This research focuses on understanding the genetic and immune profiles of triple negative breast cancer (TNBC) by analyzing tumor and germline DNA samples from patients. It aims to identify specific mutational signatures and immune responses that may influence the progression of TNBC. By utilizing whole exome sequencing, the study seeks to uncover the underlying biological mechanisms that differentiate TNBC from other breast cancer subtypes. This information could lead to more personalized treatment options for patients with TNBC.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with triple negative breast cancer, particularly those of African descent.
Not a fit: Patients with non-triple negative breast cancer subtypes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies and outcomes for patients with triple negative breast cancer.
How similar studies have performed: Previous research has shown promise in understanding the genetic and immune profiles of breast cancer, indicating that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Tamimi, Rulla M — Weill Medical Coll of Cornell Univ
- Study coordinator: Tamimi, Rulla M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.