Investigating genetic and environmental risks of liver cancer in Latinos
Genetic and Environmental risk of NAFLD-related HCC In All Latinos: the GENIAL Study
This study is looking at how genes and the environment affect the risk of liver cancer in Latino people with fatty liver disease, and it aims to include a wide range of participants to better understand these factors and improve personalized care.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project ID | NIH-10932985 on NIH RePORTER |
What this research studies
This research focuses on understanding the genetic and environmental factors that contribute to the risk of hepatocellular carcinoma (HCC) related to non-alcoholic fatty liver disease (NAFLD) specifically in Latino populations. The study aims to include a diverse group of Latino individuals to better capture the genetic variations that may influence disease risk. Researchers will utilize advanced methodologies such as genome-wide association studies (GWAS) and phenome-wide association studies to identify novel genetic associations and develop personalized risk assessments. By collaborating with existing health initiatives, the study seeks to enhance the understanding of NAFLD and HCC in a population that has been historically underrepresented in medical research.
Who could benefit from this research
Good fit: Ideal candidates for this research are Latino individuals who have been diagnosed with non-alcoholic fatty liver disease (NAFLD).
Not a fit: Patients who do not identify as Latino or who do not have NAFLD may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved risk assessment and personalized treatment strategies for Latino patients at risk of liver cancer.
How similar studies have performed: Previous research has shown success in using genome-wide association studies to identify genetic risks in other populations, suggesting that this approach could be effective in studying Latinos as well.
Where this research is happening
Coral Gables, United States
- University of Miami School of Medicine — Coral Gables, United States (Active)
Researchers
- Principal investigator: Jones, Patricia Denise — University of Miami School of Medicine
- Study coordinator: Jones, Patricia Denise
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.