Investigating genetic and environmental factors in dementia in South America
US-South American Initiative for Genetic-Neural-Behavioral Interactions in Human Neurodegenerative Research
This study is looking at how genetics and social factors affect the risk of developing Alzheimer's and frontotemporal dementia in people from South America, and it invites participants to help us learn more about their own genetic risks while contributing to important research.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10812302 on NIH RePORTER |
What this research studies
This research focuses on understanding how genetic and socioeconomic factors contribute to the development of Alzheimer's disease and frontotemporal dementia in South American countries. By establishing a large cohort of participants from Brazil, Argentina, Colombia, Peru, and the US, the study aims to identify unique risk factors that may differ from those in high-income countries. The approach includes comprehensive epidemiological investigations and genomic analyses to uncover the interplay between genetics and environmental influences on neurodegenerative disorders. Patients will be involved in data collection and may benefit from insights into their own genetic risk factors.
Who could benefit from this research
Good fit: Ideal candidates for participation include individuals from South America, particularly those with a family history of Alzheimer's disease or frontotemporal dementia.
Not a fit: Patients outside of South America or those without a genetic predisposition to dementia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and targeted interventions for dementia in South American populations.
How similar studies have performed: Previous research has shown success in identifying genetic risk factors for dementia in other populations, but this study aims to explore a relatively uncharted area in South America.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Miller, Bruce L — University of California, San Francisco
- Study coordinator: Miller, Bruce L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.