Investigating genetic and brain changes in autism at the single-cell level
Analysis of epigenetic and neuronal circuit changes in autism on the single-cell level
This study is looking at how changes in genes and their activity affect brain development in children with Autism Spectrum Disorder (ASD), using advanced techniques to find out what’s happening in their brains, which could help us understand more about the condition and its causes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-10889020 on NIH RePORTER |
What this research studies
This research focuses on understanding how genetic and epigenetic changes affect brain development in children with Autism Spectrum Disorder (ASD). By using advanced techniques like single-cell RNA sequencing and ATAC sequencing, the study aims to identify specific cellular pathways and neuronal circuits that are altered in ASD. This detailed analysis will help uncover the molecular mechanisms behind the disorder, potentially leading to new insights into its causes and effects. The research involves examining brain tissue from individuals with ASD to pinpoint the exact changes at a cellular level.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years diagnosed with Autism Spectrum Disorder.
Not a fit: Patients who are older than 11 years or do not have a diagnosis of Autism Spectrum Disorder may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for children with Autism Spectrum Disorder.
How similar studies have performed: Previous research using single-cell genomics has shown promise in understanding complex neurodevelopmental disorders, suggesting that this approach could yield valuable insights.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Velmeshev, Dmitry — Duke University
- Study coordinator: Velmeshev, Dmitry
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.