Investigating genetic and biomarker factors in Alzheimer's disease among diverse populations
Official title: Core E: Biosample Core
Funded at University of Pennsylvania · NIH-10878681 · Data updated 2026-11-12
This study is looking at the genetic clues and signs of Alzheimer's disease, especially in African Americans, to help improve how we diagnose and treat the condition for everyone.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $968,277 |
| NIH project number | 5U19AG079774-02 |
| Project ID | NIH-10878681 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation include individuals from African American backgrounds who are at risk for or diagnosed with Alzheimer's disease.
✕Less likely to help
Patients who do not identify as part of the African American population or those without a risk for Alzheimer's disease may not benefit from this research.
What this research studies
This research focuses on understanding the genetic risk factors and biomarkers associated with Alzheimer's disease (AD), particularly in underrepresented populations such as African Americans. It aims to improve the accuracy of AD diagnosis by utilizing advanced techniques like PET imaging and analyzing cerebrospinal fluid. The study seeks to address the limitations of previous research that predominantly involved individuals of European ancestry, thereby enhancing the understanding of AD across diverse genetic backgrounds. By identifying specific biomarkers and genetic variants, the research hopes to provide insights that could lead to better diagnostic tools and treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic accuracy and tailored treatment options for Alzheimer's disease in diverse populations.
How similar studies have gone: Previous research has shown success in identifying genetic risk factors and biomarkers for Alzheimer's disease, but this study aims to fill a gap by focusing on underrepresented populations.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Yu, Ho Wh — University of Pennsylvania
- Study coordinator: Yu, Ho Wh
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.