Investigating genetic and biological factors contributing to Alzheimer's disease risk in diverse populations.
Genomic, Epigenomic, and Transcriptomic Mechanisms of Contributing to Alzheimer's Disease Risk in Diverse Ancestral Populations
This study is looking at how genes and other biological factors might affect the risk of Alzheimer's disease, especially in African American and Hispanic communities, by examining blood samples from people with and without the disease to better understand what makes some people more likely to develop it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project ID | NIH-10883935 on NIH RePORTER |
What this research studies
This research focuses on understanding the genetic, epigenetic, and transcriptomic factors that contribute to the risk of Alzheimer's disease (AD) in diverse ancestral populations, particularly African Americans and Hispanics. By analyzing blood samples from individuals with AD and cognitively healthy controls, the study aims to uncover the biological mechanisms behind genetic variations associated with AD. The approach includes advanced techniques such as RNA sequencing and DNA methylation analysis to provide insights into how these factors influence disease risk. This comprehensive analysis will help fill the gaps in knowledge regarding AD in underrepresented populations.
Who could benefit from this research
Good fit: Ideal candidates for participation include individuals of African American or Hispanic descent who are either diagnosed with Alzheimer's disease or are cognitively healthy elderly individuals.
Not a fit: Patients who do not belong to the targeted ancestral populations or those who are not elderly may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potentially new strategies for preventing or treating Alzheimer's disease in diverse populations.
How similar studies have performed: Other research has shown success in exploring genetic factors related to Alzheimer's disease, but this study's focus on diverse populations is relatively novel.
Where this research is happening
Coral Gables, United States
- University of Miami School of Medicine — Coral Gables, United States (Active)
Researchers
- Principal investigator: Griswold, Anthony John — University of Miami School of Medicine
- Study coordinator: Griswold, Anthony John
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.