Investigating genes linked to Type 2 Diabetes using human stem cells and mice
Functional Interrogation of T2D-associated genes in human stem cell-derived models and mice
This study is looking at how our genes might play a role in Type 2 Diabetes, using special cells and mice to find out more, with the hope of discovering new ways to treat the condition that could help people like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10885945 on NIH RePORTER |
What this research studies
This research focuses on understanding the genetic factors that contribute to Type 2 Diabetes (T2D) by using human stem cell-derived models and mice. The team will analyze genetic variations associated with T2D to identify how these variations affect disease development and progression. By mapping these genetic factors to specific genes and biological pathways, the research aims to uncover new therapeutic targets that could lead to better treatments for T2D. Patients may benefit from the insights gained into the disease mechanisms and potential new therapies that could arise from this work.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for or diagnosed with Type 2 Diabetes.
Not a fit: Patients with Type 1 Diabetes or those without any genetic predisposition to Type 2 Diabetes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new treatments for Type 2 Diabetes, improving patient outcomes.
How similar studies have performed: Previous research has shown success in identifying genetic factors related to other complex diseases, suggesting that this approach could yield valuable insights for T2D as well.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Seale, Patrick — University of Pennsylvania
- Study coordinator: Seale, Patrick
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.