Investigating genes linked to schizophrenia and their role in brain cell interactions
Official title: Characterization of schizophrenia liability genes in models of human microglial synaptic pruning
Funded at Massachusetts General Hospital · NIH-11051873 · Data updated 2026-11-12
This study is looking at how specific genes linked to schizophrenia impact brain cells that help manage connections between neurons, with the goal of finding new ways to understand and treat the condition for people living with it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | July 12, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $503,390 |
| NIH project number | 5R01MH131687-03 |
| Project ID | NIH-11051873 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with schizophrenia or those with a family history of the disorder.
✕Less likely to help
Patients with schizophrenia who do not have identifiable genetic factors or those with other unrelated mental health conditions may not benefit from this research.
What this research studies
This research focuses on understanding how certain genes associated with schizophrenia affect the brain's microglial cells, which are responsible for pruning synapses, or connections between neurons. By using patient-derived microglia-like cells and advanced genetic engineering techniques, the researchers aim to uncover the mechanisms behind synaptic dysfunction in schizophrenia. The study will utilize a biobank of patient-specific cells to explore how these genetic factors contribute to the disease, potentially leading to new therapeutic targets. Patients may benefit from insights gained about the biological underpinnings of their condition.
Why it matters
Potential benefit: If successful, this research could lead to the development of novel treatments that target the underlying biological mechanisms of schizophrenia.
How similar studies have gone: Previous research has shown promising results in understanding the role of microglia in neurodevelopmental disorders, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Sheridan, Steven D — Massachusetts General Hospital
- Study coordinator: Sheridan, Steven D
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.