Investigating genes linked to neurodevelopmental disorders like autism.
Official title: Functional Studies of NDD Gene(s)
Funded at University of Alabama at Birmingham · NIH-11050357 · Data updated 2026-11-12
This study is looking at how certain genes might influence brain development and behavior in conditions like autism and intellectual disabilities, using specially modified mice to help find new ways to understand and treat these challenges.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project start | January 13, 2025 |
| Project end | October 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $742,484 |
| NIH project number | 1R01MH135954-01A1 |
| Project ID | NIH-11050357 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with autism spectrum disorders or related neurodevelopmental conditions.
✕Less likely to help
Patients with neurodevelopmental disorders not linked to the specific genes being studied may not benefit from this research.
What this research studies
This research focuses on understanding the genetic causes of neurodevelopmental disorders, particularly autism and intellectual disabilities. By using a genetically modified mouse model, researchers will explore how specific genes affect brain function and behavior. The study will involve advanced techniques such as RNA sequencing and MRI to analyze brain changes and behavior at different developmental stages. The goal is to provide insights that could lead to better understanding and treatment options for these disorders.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic and therapeutic strategies for individuals with neurodevelopmental disorders.
How similar studies have gone: Previous research has shown promising results in understanding genetic contributions to neurodevelopmental disorders using similar methodologies.
Where this research is happening
-
University of Alabama at Birmingham
Birmingham, United States Active
Researchers
- Principal investigator: Powell, Craig M — University of Alabama at Birmingham
- Study coordinator: Powell, Craig M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.