Investigating genes linked to neurodevelopmental and psychiatric disorders in mice
Official title: Cross Scale Interrogation of NPD Genes (SING) in mice
Funded at Pennsylvania State Univ Hershey Med Ctr · NIH-11020160 · Data updated 2026-11-12
This study is looking at how certain genes linked to brain and mental health conditions affect brain development and function, using special techniques and mice to see what happens when these genes are turned off, so we can better understand how they influence behavior and brain connections.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pennsylvania State Univ Hershey Med Ctr NIH-funded |
| Lab location | 1 site (Hershey, United States) |
| Project start | January 15, 2025 |
| Project end | November 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $3,498,931 |
| NIH project number | 1RM1MH138309-01 |
| Project ID | NIH-11020160 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals with neurodevelopmental or psychiatric disorders, particularly those with a known genetic component.
✕Less likely to help
Patients without neurodevelopmental or psychiatric disorders are unlikely to benefit from this research.
What this research studies
This research focuses on understanding how specific genes related to neurodevelopmental and psychiatric disorders (NPDs) affect brain development and function. By using advanced techniques such as single-cell and spatial transcriptomics, as well as MRI imaging, the study aims to uncover the biological pathways that lead to changes in neural circuits and behaviors. The research will involve creating knockout mice to observe the effects of deleting certain NPD genes at various developmental stages. This comprehensive approach will help identify the molecular and cellular alterations that contribute to NPDs.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the biological mechanisms of neurodevelopmental and psychiatric disorders, potentially paving the way for targeted therapies.
How similar studies have gone: Previous research has shown success in using genetic models to study neurodevelopmental disorders, indicating that this approach has the potential for meaningful discoveries.
Where this research is happening
-
Pennsylvania State Univ Hershey Med Ctr
Hershey, United States Active
Researchers
- Principal investigator: Kim, Yongsoo — Pennsylvania State Univ Hershey Med Ctr
- Study coordinator: Kim, Yongsoo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.