Investigating genes linked to neurodevelopmental and neuropsychiatric disorders
Official title: High-throughput in vivo and in vitro functional and multi-omics screens of neuropsychiatric and neurodevelopmental disorder risk genes
Funded at Yale University · NIH-11078795 · Data updated 2026-11-12
This study is looking at how certain genes might affect brain development and behavior, using special cells and zebrafish to learn more, with the hope that the findings will help improve understanding and treatment for people with neurodevelopmental and neuropsychiatric disorders.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | May 1, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $1,537,668 |
| NIH project number | 5RM1MH132648-03 |
| Project ID | NIH-11078795 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with neurodevelopmental or neuropsychiatric disorders, particularly those with a family history of such conditions.
✕Less likely to help
Patients without neurodevelopmental or neuropsychiatric disorders are unlikely to benefit from this research.
What this research studies
This research focuses on understanding the biological mechanisms behind genes that increase the risk of neurodevelopmental and neuropsychiatric disorders. By using advanced techniques involving human induced pluripotent stem cells and zebrafish, the team will conduct functional assays to observe how these genes affect brain development and behavior. Patients may benefit from insights gained through high-throughput screening of these genes, which could lead to better understanding and treatment options for related conditions.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnosis and treatment strategies for individuals with neurodevelopmental and neuropsychiatric disorders.
How similar studies have gone: Previous research has shown promise in using similar high-throughput screening methods to identify genetic factors in neurodevelopmental disorders.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Hoffman, Ellen J — Yale University
- Study coordinator: Hoffman, Ellen J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.