Investigating genes linked to autism using zebrafish models
High-throughput Functional Analysis of Autism Risk Genes
This study is looking at how certain genes linked to autism affect brain development and function, using zebrafish to help find new ways to understand and potentially treat autism in people.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11049823 on NIH RePORTER |
What this research studies
This research focuses on understanding the biological mechanisms behind autism spectrum disorders (ASDs) by analyzing specific genes associated with the condition. Using a high-throughput zebrafish system, researchers will conduct in vivo functional analyses of multiple ASD genes simultaneously. The study aims to identify molecular signatures and cellular mechanisms that contribute to the development of autism, with the goal of translating findings to human cells. By examining the effects of these genes on brain structure and activity, the research seeks to uncover potential pathways for treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with autism spectrum disorders or those with a family history of ASD.
Not a fit: Patients with autism who do not have genetic links to the identified ASD genes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and potential treatments for individuals with autism spectrum disorders.
How similar studies have performed: Other research has shown promise in using zebrafish models to study genetic conditions, indicating that this approach could yield valuable insights.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Hoffman, Ellen J — Yale University
- Study coordinator: Hoffman, Ellen J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.