Investigating genes linked to autism and their effects on development
Official title: Functional analysis of histone modifier Autism Spectrum Disorders risk genes in vertebrate development
Funded at University of California Los Angeles · NIH-11080440 · Data updated 2026-11-12
This study is looking at how certain genes related to autism impact brain development and behavior by using zebrafish, which share some genetic similarities with humans, to help us understand how changes in these genes might affect how the brain works and behaves, with the hope of finding new ways to help those with autism.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $248,999 |
| NIH project number | 4R00HD105001-03 |
| Project ID | NIH-11080440 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research are individuals diagnosed with autism spectrum disorders or those with a family history of autism.
✕Less likely to help
Patients with autism who do not have mutations in the specific histone modifier genes being studied may not benefit from this research.
What this research studies
This research focuses on understanding how specific genes associated with autism affect brain development and behavior. By using zebrafish, a model organism with similar genetic traits to humans, researchers will analyze how mutations in these genes lead to changes in behavior and neural cell types. The study aims to systematically dissect the roles of histone modifier genes linked to autism, providing insights into the underlying mechanisms of the disorder. This could help identify potential targets for therapeutic interventions.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for individuals with autism spectrum disorders.
How similar studies have gone: Previous research has shown success in using zebrafish models to study genetic influences on behavior, indicating that this approach is promising.
Where this research is happening
-
University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Tornini, Valerie Angela — University of California Los Angeles
- Study coordinator: Tornini, Valerie Angela
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.