Investigating genes linked to autism and their effects on behavior
Official title: High-throughput interrogation of autism risk genes: from molecules to behavior
Funded at University of Texas at Austin · NIH-11047741 · Data updated 2026-11-12
This study is looking at how certain genes linked to autism spectrum disorder (ASD) affect social behaviors by using tiny worms called C. elegans, and it aims to find out if fixing these genes can help improve social interactions, which could give us a better understanding of the genetics behind ASD.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas at Austin NIH-funded |
| Lab location | 1 site (Austin, United States) |
| Project start | May 1, 2023 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $331,293 |
| NIH project number | 5R01MH133243-03 |
| Project ID | NIH-11047741 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with autism spectrum disorder or those with a family history of ASD.
✕Less likely to help
Patients without a diagnosis of autism spectrum disorder or those not genetically predisposed to ASD may not benefit from this research.
What this research studies
This research explores how specific genes associated with autism spectrum disorder (ASD) influence social behaviors using the nematode C. elegans as a model organism. By analyzing various genetically distinct strains of C. elegans, the study aims to identify the relationship between mutations in ASD risk genes and social behavior deficits. The researchers will replace defective genes with functional ones to observe any improvements in social interactions, providing insights into the genetic basis of ASD. This approach allows for rapid testing of multiple gene variants, which is more efficient than traditional rodent models.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of the genetic factors contributing to autism, potentially informing new therapeutic strategies.
How similar studies have gone: Previous research using C. elegans has shown promise in understanding neurological conditions, suggesting that this approach could yield valuable insights into autism.
Where this research is happening
-
University of Texas at Austin
Austin, United States Active
Researchers
- Principal investigator: Pierce, Jonathan Thomas — University of Texas at Austin
- Study coordinator: Pierce, Jonathan Thomas
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.