Investigating genes involved in childhood glaucoma development
Single cell transcriptome profiling of aqueous humor outflow development for discovery of novel childhood glaucoma genes
This study is looking at how certain genes might cause primary congenital glaucoma, a serious eye condition in babies, especially boys, to help find better treatments for kids who have it.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-10682543 on NIH RePORTER |
What this research studies
This research focuses on understanding primary congenital glaucoma (PCG), a severe eye disorder affecting infants, particularly boys. By analyzing the gene expression during the development of the aqueous humor outflow structures in the eye, the researchers aim to identify new genes that contribute to this condition. The study utilizes advanced techniques in single-cell transcriptome profiling to uncover the molecular mechanisms behind PCG, which could lead to better treatment options for affected children.
Who could benefit from this research
Good fit: Ideal candidates for this research are infants and young children diagnosed with primary congenital glaucoma.
Not a fit: Patients with glaucoma not related to congenital causes or those outside the age range of 0-11 years may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the discovery of new genetic targets for treating childhood glaucoma, potentially preventing blindness in affected infants.
How similar studies have performed: Previous research has successfully identified genetic factors in other forms of glaucoma, suggesting that this approach may yield valuable insights for PCG as well.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Tompson, Stuart William James — University of Wisconsin-Madison
- Study coordinator: Tompson, Stuart William James
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.