Investigating gene regulation using synthetic DNA technology
Synthetic HoxA to dissect transcriptional regulatory logic - TRFR
This study is looking at how certain genes help control the development of cells, especially in turning stem cells into motor neurons, using special techniques in yeast to test different gene versions, and it's aimed at anyone interested in understanding how our genes work during growth.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10898806 on NIH RePORTER |
What this research studies
This research focuses on understanding how specific genes, particularly those in the HoxA cluster, regulate developmental processes. By utilizing advanced synthetic DNA techniques, the team can create and test various gene variants in yeast, which allows for rapid and precise experimentation. The goal is to explore how these gene variants function in mouse embryonic stem cells, particularly in their differentiation into motor neurons. This innovative approach aims to uncover the complexities of gene regulation and its implications for development.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals under 20 years of age who may have genetic conditions related to developmental processes.
Not a fit: Patients with conditions unrelated to genetic regulation or those over the age of 20 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into gene regulation that may improve treatments for developmental disorders.
How similar studies have performed: Other research using synthetic DNA technology has shown promise in understanding gene regulation, indicating that this approach could yield valuable insights.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Mazzoni, Esteban Orlando — New York University School of Medicine
- Study coordinator: Mazzoni, Esteban Orlando
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.