Investigating gene regulation linked to schizophrenia using advanced CRISPR techniques
Official title: Understanding gene regulation in schizophrenia-associated loci using high-throughput epigenetic CRISPR screens
Funded at Duke University · NIH-10993269 · Data updated 2026-11-12
This study is looking at how certain genes might play a role in schizophrenia, using a special tool called CRISPR to explore these genetic factors, and the findings could help develop new treatments for people living with this condition.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | July 11, 2024 |
| Project end | July 10, 2027 |
| Funding year | 2024 |
| Award (this year) | $42,519 |
| NIH project number | 1F31MH138142-01 |
| Project ID | NIH-10993269 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with schizophrenia or those with a family history of the disorder.
✕Less likely to help
Patients without a diagnosis of schizophrenia or those not genetically predisposed to the condition may not benefit from this research.
What this research studies
This research focuses on understanding the genetic factors that contribute to schizophrenia by using high-throughput CRISPR screens. The approach involves identifying non-coding genetic variants associated with schizophrenia and determining how they regulate gene expression. By employing CRISPR-Cas9 technology, researchers aim to dissect these variants at a large scale, linking them to their target genes and enhancing our understanding of the genetic basis of this complex disorder. Patients may benefit from insights gained that could lead to new therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for individuals with schizophrenia.
How similar studies have gone: Other research utilizing CRISPR technology has shown promise in understanding genetic disorders, suggesting that this approach could yield valuable insights into schizophrenia as well.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Hamilton, Marisa C. — Duke University
- Study coordinator: Hamilton, Marisa C.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.