Investigating gene function in the eye using advanced genetic techniques
Official title: Mosaic in Vivo Perturbation (MVP) for systematic assessment of gene function in the eye
Funded at Harvard Medical School · NIH-10940839 · Data updated 2026-11-12
This study is testing a new way to understand how genes work in the eye using zebrafish, which could help us learn more about eye health and diseases that affect vision.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard Medical School NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 1, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $693,571 |
| NIH project number | 1R01EY036381-01 |
| Project ID | NIH-10940839 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic eye disorders or those interested in the genetic basis of eye health.
✕Less likely to help
Patients with non-genetic eye conditions or those not affected by genetic factors may not benefit from this research.
What this research studies
This research focuses on developing a new method called Mosaic in Vivo Perturbation (MVP) to systematically assess gene function in the eye. By utilizing advanced technologies like single-cell RNA sequencing and CRISPR/Cas9, the researchers aim to overcome challenges in traditional genetic screening methods, such as gene redundancy and pleiotropy. The study will involve animal models, particularly zebrafish, to explore how genes function in various biological processes and diseases. This innovative approach could lead to a better understanding of genetic contributions to eye health and disease.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of genetic factors affecting eye health, potentially leading to new treatments for eye diseases.
How similar studies have gone: Other research using CRISPR and advanced genetic screening methods has shown promise in understanding gene functions, indicating that this approach could be successful.
Where this research is happening
-
Harvard Medical School
Boston, United States Active
Researchers
- Principal investigator: Klein, Allon Moshe — Harvard Medical School
- Study coordinator: Klein, Allon Moshe
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.