Investigating gene expression related to depression in people with HIV
Immunometabolicgene expression profiles associated with depressed mood and behavioral domains inpeople with HIV
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA, SAN DIEGO · NIH-10901842
This study is looking at how the body's immune and metabolism systems might influence depression in people living with HIV, and it will help us understand the connection between certain genes and feelings of pleasure, so we can learn more about how to support those dealing with depression.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN DIEGO (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-10901842 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how immunometabolism affects depression in individuals living with HIV. It aims to identify specific gene expression profiles that are linked to symptoms of depression, particularly anhedonia, which is the inability to feel pleasure. By analyzing blood samples and using advanced RNA sequencing techniques, the study will explore the relationship between these gene expressions and clinical depression, as well as cognitive functions impacted by depression. The research will involve 80 participants with HIV and 40 age-matched individuals without HIV to compare findings.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who experience symptoms of depression, particularly those who have not responded well to standard antidepressant treatments.
Not a fit: Patients who do not have HIV or those who do not experience depressive symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new, targeted treatments for depression in people living with HIV.
How similar studies have performed: Previous research has shown promising results in understanding the relationship between immunometabolism and depression, suggesting that this approach could yield valuable insights.
Where this research is happening
LA JOLLA, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN DIEGO — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ELLIS, RONALD J. — UNIVERSITY OF CALIFORNIA, SAN DIEGO
- Study coordinator: ELLIS, RONALD J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus, Affective Disorders