Investigating gene expression differences in alcohol use disorder
Single cell transcriptomic study of alcohol use
This study is looking at how alcohol use disorder affects brain cells by analyzing brain samples to see how different types of cells behave, which could help create better treatments for people struggling with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Virginia Commonwealth University NIH-funded |
| Lab location | 1 site (Richmond, United States) |
| Project ID | NIH-10916177 on NIH RePORTER |
What this research studies
This research focuses on understanding alcohol use disorder (AUD) by examining gene expression at a cellular level in post-mortem brain samples. By utilizing advanced single nucleus RNA sequencing technology, the study aims to identify specific cell types and their gene expression patterns associated with AUD. This approach allows for a more nuanced understanding of how different cells contribute to the disorder, which could lead to better-targeted interventions. The findings may help in developing new clinical strategies to address AUD more effectively.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of alcohol use disorder, particularly those who have undergone post-mortem examination.
Not a fit: Patients who do not have a history of alcohol use disorder or who are currently in recovery without significant past alcohol use may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and interventions for individuals suffering from alcohol use disorder.
How similar studies have performed: Previous research using single cell transcriptomics has shown promise in understanding various disorders, suggesting that this approach could yield valuable insights into alcohol use disorder as well.
Where this research is happening
Richmond, United States
- Virginia Commonwealth University — Richmond, United States (Active)
Researchers
- Principal investigator: Van Den Oord, Edwin — Virginia Commonwealth University
- Study coordinator: Van Den Oord, Edwin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.