Investigating gene expression and immune cell regulation using advanced sequencing techniques
Gene expression, Epigenetics and Bioinformatics Core
This study is looking at how our genes and the way they are organized affect how our immune system works, especially in certain immune cells, to help find better treatments for immune-related conditions.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-10885040 on NIH RePORTER |
What this research studies
This research focuses on understanding how gene expression and chromatin structure influence the immune response, particularly in T and B cells. By utilizing advanced next-generation sequencing (NGS) techniques, the project aims to analyze gene loss-of-function screens, chromatin accessibility, and RNA expression from small numbers of immune cells. Patients may benefit from insights gained about immune regulation, which could lead to improved treatments for immune-related conditions. The research employs a combination of innovative computational approaches and standardized methods to ensure reliable results.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with immune system disorders or those interested in the genetic basis of immune function.
Not a fit: Patients with non-immune related conditions or those not interested in genetic research may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing immune responses in patients with immune disorders.
How similar studies have performed: Previous research using similar next-generation sequencing approaches has shown promise in understanding immune cell regulation and gene expression.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Pipkin, Matthew Eugene — University of Florida
- Study coordinator: Pipkin, Matthew Eugene
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.