Investigating gene changes in the brains of Alzheimer's patients
Altered reverse transcriptase-dependent gene diversification mechanisms in Alzheimer's disease brains
This study is looking at how changes in certain genes in the brains of people with Alzheimer's might help us find new ways to treat the disease, focusing on a specific gene linked to Alzheimer's.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sanford Burnham Prebys Medical Discovery Institute NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10769748 on NIH RePORTER |
What this research studies
This research explores how certain gene changes occur in the brains of individuals with Alzheimer's disease, particularly focusing on a process called somatic gene recombination. By analyzing brain samples from patients, the study aims to identify new molecular targets that could lead to innovative therapies for Alzheimer's. The researchers are specifically looking at variations in the Amyloid Precursor Protein gene, which is known to be involved in the disease. The approach combines advanced genetic techniques to understand how these changes may contribute to Alzheimer's progression.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with sporadic Alzheimer's disease who are willing to provide postmortem brain samples.
Not a fit: Patients with early-onset Alzheimer's or those without a confirmed diagnosis of sporadic Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options that target the underlying genetic mechanisms of Alzheimer's disease.
How similar studies have performed: Other research has shown promising results in understanding genetic changes in Alzheimer's, but this specific approach focusing on somatic gene recombination is relatively novel.
Where this research is happening
La Jolla, United States
- Sanford Burnham Prebys Medical Discovery Institute — La Jolla, United States (Active)
Researchers
- Principal investigator: Chun, Jerold — Sanford Burnham Prebys Medical Discovery Institute
- Study coordinator: Chun, Jerold
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.