Investigating gene changes in the brain related to Alzheimer's disease
Transformative research on somatic gene recombination in the normal and Alzheimer's disease-related dementia brain
This study is looking at how changes in brain genes might play a role in Alzheimer's and other types of dementia, hoping to find new ways to help treat these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sanford Burnham Prebys Medical Discovery Institute NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10841012 on NIH RePORTER |
What this research studies
This research focuses on understanding how somatic gene recombination (SGR) in the brain may contribute to Alzheimer's disease and related dementias. By examining how neural activity can influence gene sequences in neurons, the study aims to uncover new mechanisms that could explain disease progression. The researchers will analyze gene variants associated with Alzheimer's and explore how SGR might be a common factor in various dementias. This could lead to new insights into potential therapeutic targets for these conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or related dementias.
Not a fit: Patients with other forms of dementia not related to Alzheimer's or those without cognitive impairments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that modify the progression of Alzheimer's disease and improve cognitive function.
How similar studies have performed: While the concept of somatic gene recombination is relatively novel, previous studies have shown promise in understanding genetic factors in neurodegenerative diseases.
Where this research is happening
La Jolla, United States
- Sanford Burnham Prebys Medical Discovery Institute — La Jolla, United States (Active)
Researchers
- Principal investigator: Chun, Jerold — Sanford Burnham Prebys Medical Discovery Institute
- Study coordinator: Chun, Jerold
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.