Investigating gene changes and brain circuit functions in Alzheimer's disease
Transcriptomic and Circuitry Aberrations in Alzheimer’s Disease
This study is looking at how certain gene changes in the brain might lead to memory and thinking problems in the early stages of Alzheimer's disease, and it aims to find ways to help treat these issues before they get worse.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University of New York at Buffalo NIH-funded |
| Lab location | 1 site (Amherst, United States) |
| Project ID | NIH-10983355 on NIH RePORTER |
What this research studies
This research focuses on understanding how specific gene changes in the brain contribute to cognitive decline in Alzheimer's disease (AD) at early stages. By analyzing brain tissues and neurons derived from patients, the study aims to identify key molecular pathways that are disrupted before significant neurodegeneration occurs. The researchers will utilize advanced techniques, including RNA sequencing and electrophysiological recordings, to uncover how these changes affect brain circuit functions. This approach may help in pinpointing targets for early intervention in AD.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with early-stage Alzheimer's disease or those with a family history of the condition.
Not a fit: Patients with advanced Alzheimer's disease or other forms of dementia unrelated to Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for early diagnosis and treatment of Alzheimer's disease, potentially slowing cognitive decline.
How similar studies have performed: Previous research has shown promising results in identifying molecular changes in Alzheimer's, suggesting that this approach could yield valuable insights.
Where this research is happening
Amherst, United States
- State University of New York at Buffalo — Amherst, United States (Active)
Researchers
- Principal investigator: Yan, Zhen — State University of New York at Buffalo
- Study coordinator: Yan, Zhen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.