Investigating gene changes and brain circuit functions in Alzheimer's disease
Official title: Transcriptomic and Circuitry Aberrations in Alzheimer’s Disease
Funded at State University of New York at Buffalo · NIH-10983355 · Data updated 2026-11-12
This study is looking at how certain gene changes in the brain might lead to memory and thinking problems in the early stages of Alzheimer's disease, and it aims to find ways to help treat these issues before they get worse.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University of New York at Buffalo NIH-funded |
| Lab location | 1 site (Amherst, United States) |
| Project start | December 1, 2022 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $668,772 |
| NIH project number | 5R01AG079797-03 |
| Project ID | NIH-10983355 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with early-stage Alzheimer's disease or those with a family history of the condition.
✕Less likely to help
Patients with advanced Alzheimer's disease or other forms of dementia unrelated to Alzheimer's may not benefit from this research.
What this research studies
This research focuses on understanding how specific gene changes in the brain contribute to cognitive decline in Alzheimer's disease (AD) at early stages. By analyzing brain tissues and neurons derived from patients, the study aims to identify key molecular pathways that are disrupted before significant neurodegeneration occurs. The researchers will utilize advanced techniques, including RNA sequencing and electrophysiological recordings, to uncover how these changes affect brain circuit functions. This approach may help in pinpointing targets for early intervention in AD.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for early diagnosis and treatment of Alzheimer's disease, potentially slowing cognitive decline.
How similar studies have gone: Previous research has shown promising results in identifying molecular changes in Alzheimer's, suggesting that this approach could yield valuable insights.
Where this research is happening
-
State University of New York at Buffalo
Amherst, United States Active
Researchers
- Principal investigator: Yan, Zhen — State University of New York at Buffalo
- Study coordinator: Yan, Zhen
Related research
Other NIH-funded projects on the same topics.
-
Understanding how brain activity changes may drive Alzheimer’s disease progression in a mouse model
Researchers are testing how changes in brain signals and protein cleanup processes affect the development of Alzheimer’s disease in mice.
-
Thiamine-boosting therapy for Alzheimer’s: understanding how benfotiamine may reduce harmful AGE in DP patients
A medication-based approach using high-dose vitamin B1 (benfotiamine) is studied to help people with Alzheimer's by reducing harmful sugar-related molecules.
-
Non-invasive tears biomarker for early Alzheimer's in LMICs
A low-cost, tear-based biomarker approach aims to detect early Alzheimer’s disease in older adults in Peru and similar settings.
-
Turning APOE4 into protective APOE2 or APOE3Christchurch to help with Alzheimer’s
A patient-facing explanation of a treatment idea that aims to change a genetic risk factor for Alzheimer's disease in the brain.
-
Telomerase in Alzheimer’s Disease: how aging biology could influence memory and brain health
Researchers are exploring a new brain-aging mechanism linked to telomerase, with potential to slow or modify Alzheimer’s disease in people and improve cognitive function.
-
Biomarkers of Alzheimer’s Disease: Sensory, Motor, and Cognitive Clues
Researchers are testing simple sensory and movement tasks to find early signs of Alzheimer’s disease so they can diagnose and treat people sooner.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.