Investigating Fuchs Corneal Endothelial Dystrophy using mouse models
Official title: Models of Fuchs Corneal Endothelial Dystrophy
Funded at Trustees of Indiana University · NIH-11080952 · Data updated 2026-11-12
This study is looking at Fuchs corneal endothelial dystrophy (FECD) by using mice to mimic how the disease develops, so researchers can better understand it and find new ways to treat it.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Trustees of Indiana University NIH-funded |
| Lab location | 1 site (Bloomington, United States) |
| Project start | May 1, 2024 |
| Project end | April 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $198,125 |
| NIH project number | 5R21EY036160-02 |
| Project ID | NIH-11080952 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals over the age of 40, particularly women, who are experiencing symptoms of Fuchs corneal endothelial dystrophy.
✕Less likely to help
Patients with other types of corneal diseases or those under the age of 40 may not benefit from this research.
What this research studies
This research focuses on understanding Fuchs corneal endothelial dystrophy (FECD), a condition that affects the cornea's ability to maintain transparency due to cell death and membrane thickening. Using mouse models, the researchers aim to replicate the disease's progression by manipulating specific genes related to oxidative stress and cell death. The study will explore how these changes lead to the formation of guttae and corneal edema, which are characteristic of FECD. By inducing specific genetic modifications, the researchers hope to create a more accurate model of the disease that can help in developing potential treatments.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients suffering from Fuchs corneal endothelial dystrophy.
How similar studies have gone: Previous research has shown promise in using genetic models to study corneal diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Trustees of Indiana University
Bloomington, United States Active
Researchers
- Principal investigator: Ogando, Diego — Trustees of Indiana University
- Study coordinator: Ogando, Diego
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.