Investigating Fuchs Corneal Endothelial Dystrophy using mouse models
Models of Fuchs Corneal Endothelial Dystrophy
['FUNDING_R21'] · TRUSTEES OF INDIANA UNIVERSITY · NIH-11080952
This study is looking at Fuchs corneal endothelial dystrophy (FECD) by using mice to mimic how the disease develops, so researchers can better understand it and find new ways to treat it.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | TRUSTEES OF INDIANA UNIVERSITY (nih funded) |
| Locations | 1 site (BLOOMINGTON, UNITED STATES) |
| Trial ID | NIH-11080952 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding Fuchs corneal endothelial dystrophy (FECD), a condition that affects the cornea's ability to maintain transparency due to cell death and membrane thickening. Using mouse models, the researchers aim to replicate the disease's progression by manipulating specific genes related to oxidative stress and cell death. The study will explore how these changes lead to the formation of guttae and corneal edema, which are characteristic of FECD. By inducing specific genetic modifications, the researchers hope to create a more accurate model of the disease that can help in developing potential treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals over the age of 40, particularly women, who are experiencing symptoms of Fuchs corneal endothelial dystrophy.
Not a fit: Patients with other types of corneal diseases or those under the age of 40 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients suffering from Fuchs corneal endothelial dystrophy.
How similar studies have performed: Previous research has shown promise in using genetic models to study corneal diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
BLOOMINGTON, UNITED STATES
- TRUSTEES OF INDIANA UNIVERSITY — BLOOMINGTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: OGANDO, DIEGO — TRUSTEES OF INDIANA UNIVERSITY
- Study coordinator: OGANDO, DIEGO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.