Investigating Fragile X syndrome using human brain models
Project 3
This study is looking at Fragile X syndrome, a genetic condition that affects learning and behavior, by creating mini brain models from human cells to find better treatments that could help improve the lives of those with the condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-10907601 on NIH RePORTER |
What this research studies
This research focuses on Fragile X syndrome (FXS), a genetic condition that leads to intellectual disability and is a significant cause of autism spectrum disorders. The team is developing human-derived brain models from induced pluripotent stem cells (iPSCs) to better understand the disease mechanisms and identify potential therapeutic targets. By creating three-dimensional (3D) organoid cultures, they aim to replicate human brain development and evaluate new treatment approaches that could improve cognitive and behavioral outcomes for affected individuals. This innovative methodology allows for more accurate testing of therapies that may not be possible in traditional animal models.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Fragile X syndrome or those with a family history of the condition.
Not a fit: Patients without Fragile X syndrome or related genetic conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of effective therapies for individuals with Fragile X syndrome and related autism spectrum disorders.
How similar studies have performed: Previous research using similar human iPSC models has shown promise in understanding genetic disorders, suggesting potential for success in this novel approach.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Jin, Peng — Emory University
- Study coordinator: Jin, Peng
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.