Investigating fatigue in Veterans with chronic kidney disease through exercise
Official title: Objective and subjective measures of fatigability in Veterans with chronic kidney disease before and after flywheel resistance plus aerobic exercise
Funded at U.s. Dept/vets Affairs Medical Center · NIH-10938014 · Data updated 2026-11-12
This study is looking at how tiredness affects Veterans with chronic kidney disease and whether a special exercise program that mixes strength and aerobic workouts can help them feel less fatigued and improve their physical abilities.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | U.s. Dept/vets Affairs Medical Center NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project start | October 1, 2020 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| NIH project number | 5IK2RX003423-05 |
| Project ID | NIH-10938014 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are Veterans diagnosed with stage 3 or 4 chronic kidney disease who experience significant fatigue.
✕Less likely to help
Patients with advanced chronic kidney disease requiring dialysis or those with other severe comorbidities may not benefit from this research.
What this research studies
This research focuses on understanding how fatigue affects Veterans with chronic kidney disease (CKD) and explores the impact of a specific exercise program combining flywheel resistance exercise and aerobic training. The study aims to assess both objective and subjective measures of fatigability before and after the exercise intervention. By examining the relationship between neuromuscular capacity and fatigue, the research seeks to determine if this combined exercise approach can enhance physical function and reduce fatigue levels in affected individuals.
Why it matters
Potential benefit: If successful, this research could lead to improved exercise interventions that enhance physical function and reduce fatigue in Veterans with chronic kidney disease.
How similar studies have gone: Previous research has shown that flywheel resistance exercise can improve muscle strength and function in healthy populations, suggesting potential benefits for Veterans with CKD, although this specific combination approach is relatively novel.
Where this research is happening
-
U.s. Dept/vets Affairs Medical Center
Washington, United States Active
Researchers
- Principal investigator: Gollie, Jared M. — U.s. Dept/vets Affairs Medical Center
- Study coordinator: Gollie, Jared M.
Related research
Other NIH-funded projects on the same topics.
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Improving energy and strength in Veterans with chronic kidney disease using flywheel resistance plus aerobic exercise
This project sees whether adding aerobic workouts to flywheel resistance training can reduce tiredness and boost strength in Veterans with stage 3–4 chronic kidney disease.
-
Personalized CKD-MBD care using systems biology and AI
A patient-facing program aims to tailor mineral-balance therapy for people with chronic kidney disease by using a computer model and smart decision rules to predict who will respond best to treatments.
-
Mitigating DKA in people with type 1 diabetes and kidney disease using SGLT1/2 inhibitors
This project tests a new way to prevent dangerous diabetic ketoacidosis in people with type 1 diabetes and chronic kidney disease who are using SGLT inhibitors, by tracking ketones in real time and combining glucose-keton data for safer therapy.
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Chronic Kidney Disease in Children: following young people as they grow up with CKD
A long-term study in kids with chronic kidney disease tracks kidney function and heart health as they transition into adulthood.
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Chronic Kidney Disease in Children follow-up study
A long-term study that follows kids with kidney disease as they grow into young adults, collecting health data from home and official records.
-
Malaria-related kidney injury and its link to chronic kidney disease in children
This grant looks at why some children who have malaria develop kidney injury and later chronic kidney disease, focusing on how severe malaria affects the kidneys over time.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.