Investigating factors that lead to aggressive prostate cancer changes
Project 3: Analysis of intrinsic and extrinsic factors that promote prostate neuroendocrine differentiation
This study is looking at how certain factors might lead to a more aggressive type of prostate cancer that can develop after treatment, and it's for anyone interested in understanding this condition better and finding new ways to treat it.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11078876 on NIH RePORTER |
What this research studies
This research focuses on understanding how certain factors influence the development of neuroendocrine prostate cancer, a highly aggressive form of prostate cancer that can arise after treatment with anti-androgens. The team will analyze both normal and cancerous prostate tissues to identify key regulatory programs and signals that contribute to neuroendocrine differentiation. By utilizing advanced techniques such as single-cell RNA sequencing and computational analyses, they aim to uncover the mechanisms behind this transformation and identify potential targets for therapy.
Who could benefit from this research
Good fit: Ideal candidates for this research are men diagnosed with castration-resistant prostate cancer, particularly those exhibiting neuroendocrine features.
Not a fit: Patients with early-stage prostate cancer or those not resistant to castration therapies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies for patients with aggressive prostate cancer.
How similar studies have performed: Previous research has shown promising results in understanding neuroendocrine differentiation in prostate cancer, suggesting that this approach may yield valuable insights.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Shen, Michael M. — Columbia University Health Sciences
- Study coordinator: Shen, Michael M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.