Investigating factors that increase throat cancer risk in people living with HIV
Official title: Onco-immunologic factors contributing to OPSCC among people living with HIV
Funded at University of Alabama at Birmingham · NIH-10892466 · Data updated 2026-11-12
This study is looking into why oropharyngeal cancer happens more often in people with HIV, especially those with high-risk HPV, and it needs participants to help find out how HIV and HPV work together to increase cancer risk.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project start | September 20, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $672,147 |
| NIH project number | 1R01DE033864-01 |
| Project ID | NIH-10892466 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV who are at risk for oropharyngeal cancer, particularly those with a history of HPV infection.
✕Less likely to help
Patients who do not have HIV or those without any risk factors for oropharyngeal cancer may not benefit from this research.
What this research studies
This research focuses on understanding why oropharyngeal cancer (OPC) is more common in individuals living with HIV, particularly those infected with high-risk human papillomaviruses (HPV). The study examines how ongoing HIV replication and the immune response affect the development of OPC. By analyzing the interactions between HIV proteins and HPV oncogenic proteins, the research aims to uncover mechanisms that lead to increased cancer risk. Patients may be involved in providing samples or data to help identify these factors.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment strategies for oropharyngeal cancer in people living with HIV.
How similar studies have gone: Other research has indicated a link between HIV and increased cancer risk, suggesting that this investigation builds on established findings rather than exploring a completely novel area.
Where this research is happening
-
University of Alabama at Birmingham
Birmingham, United States Active
Researchers
- Principal investigator: Bansal, Anju — University of Alabama at Birmingham
- Study coordinator: Bansal, Anju
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.