Investigating factors that help regenerate cardiovascular tissues
Official title: Cardiovascular regeneration and pioneer factors
Funded at University of Minnesota · NIH-11110292 · Data updated 2026-11-12
This study is looking at how a special factor called ETV2 can help heal blood vessels, which could lead to better treatments for people with serious blood flow problems, like those needing bypass surgery or dealing with peripheral artery disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | May 20, 2023 |
| Project end | April 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $697,432 |
| NIH project number | 5R01HL168647-03 |
| Project ID | NIH-11110292 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults over 21 years old who are suffering from cardiovascular diseases, particularly those with peripheral artery disease or those who have undergone coronary artery bypass grafting.
✕Less likely to help
Patients with non-cardiovascular conditions or those under 21 years old may not benefit from this research.
What this research studies
This research focuses on understanding how certain factors can promote the regeneration of cardiovascular tissues, which is crucial for patients suffering from severe vascular diseases. The team will explore the role of a specific pioneer factor, ETV2, that influences the development of blood vessels and endothelial cells. Using advanced techniques like gene editing and sequencing, they aim to uncover new therapeutic strategies that could improve outcomes for patients with conditions like peripheral artery disease and those requiring bypass surgeries.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that enhance cardiovascular regeneration and reduce the need for amputations or bypass surgeries.
How similar studies have gone: Previous studies have shown promise in using pioneer factors for tissue regeneration, suggesting that this approach could lead to significant advancements in cardiovascular treatment.
Where this research is happening
-
University of Minnesota
Minneapolis, United States Active
Researchers
- Principal investigator: Garry, Daniel J. — University of Minnesota
- Study coordinator: Garry, Daniel J.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.