Investigating factors that help regenerate cardiovascular tissues
Cardiovascular regeneration and pioneer factors
This study is looking at how a special factor called ETV2 can help heal blood vessels, which could lead to better treatments for people with serious blood flow problems, like those needing bypass surgery or dealing with peripheral artery disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-11110292 on NIH RePORTER |
What this research studies
This research focuses on understanding how certain factors can promote the regeneration of cardiovascular tissues, which is crucial for patients suffering from severe vascular diseases. The team will explore the role of a specific pioneer factor, ETV2, that influences the development of blood vessels and endothelial cells. Using advanced techniques like gene editing and sequencing, they aim to uncover new therapeutic strategies that could improve outcomes for patients with conditions like peripheral artery disease and those requiring bypass surgeries.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults over 21 years old who are suffering from cardiovascular diseases, particularly those with peripheral artery disease or those who have undergone coronary artery bypass grafting.
Not a fit: Patients with non-cardiovascular conditions or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that enhance cardiovascular regeneration and reduce the need for amputations or bypass surgeries.
How similar studies have performed: Previous studies have shown promise in using pioneer factors for tissue regeneration, suggesting that this approach could lead to significant advancements in cardiovascular treatment.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Garry, Daniel J. — University of Minnesota
- Study coordinator: Garry, Daniel J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.