Investigating factors affecting growth and development in children exposed to HIV during pregnancy
Drug, microbiome, and immune determinants of birth and neurodevelopmental outcomes in children with exposure to HIV infection
This study is looking at how certain medications, breastmilk, and immune responses might affect the growth and development of children who were exposed to HIV before birth but are not infected, to help understand any challenges they may face as they grow up.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10381032 on NIH RePORTER |
What this research studies
This research focuses on children who were exposed to HIV in the womb but are not infected themselves. It aims to understand how maternal medications, the microbiome, and immune responses affect their growth and neurodevelopment. The study will involve three projects that analyze different factors, including the use of a specific medication called dolutegravir, the role of breastmilk components, and immune activation related to cytomegalovirus. By examining these elements, the research seeks to identify mechanisms that contribute to developmental challenges in these children.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years who were exposed to HIV during pregnancy but are not infected.
Not a fit: Patients who are HIV-infected or older than 11 years may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved health outcomes and developmental support for children exposed to HIV in utero.
How similar studies have performed: Previous studies have shown early differences in the gut microbiome of children exposed to HIV, indicating that this research builds on existing findings.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: John-Stewart, Grace C. — University of Washington
- Study coordinator: John-Stewart, Grace C.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.