Investigating factors affecting cognitive and physical impairment in older adults.

Genetic and Non-Genetic Modulators of Morbidity/Disability Compression in a Large Population-Based Study of Cognitive and Physical Impairment with Emphasis on Alzheimer's Disease and Related Dementias

NIH-funded research Duke University · NIH-10848268

This study looks at how both genes and other factors affect the health and daily activities of older adults, especially those with Alzheimer's and similar conditions, to find ways to help them live better lives.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionDuke University NIH-funded
Lab location1 site (Durham, United States)
Project IDNIH-10848268 on NIH RePORTER

What this research studies

This research examines how both genetic and non-genetic factors influence the health and functional abilities of older adults, particularly focusing on conditions like Alzheimer's disease and related dementias. By analyzing data from a large population-based study, the research aims to understand the trends in cognitive impairment and disability among the elderly. The methodology includes comprehensive analyses of existing health data to identify patterns and potential interventions that could improve daily living functions for seniors.

Who could benefit from this research

Good fit: Ideal candidates for this research are older adults, particularly those aged 65 and above, who may be experiencing cognitive decline or are at risk for Alzheimer's disease and related dementias.

Not a fit: Patients who are younger than 65 or do not have concerns related to cognitive impairment or Alzheimer's disease may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to improved strategies for maintaining cognitive health and functional independence in older adults.

How similar studies have performed: Previous studies have shown promising results in understanding cognitive impairment trends, suggesting that this research builds on established findings in the field.

Where this research is happening

Durham, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.