Investigating factors affecting Clostridioides difficile and inflammatory bowel disease in children
Immune, Microbial, and Metabolic Factors that Impact Clostridioides difficile and Inflammatory Bowel Disease in Children
This study is looking at how the immune system, gut bacteria, and metabolism affect children with inflammatory bowel disease (IBD) and their risk of getting Clostridioides difficile infections (CDI), with the hope of finding better ways to diagnose and treat these kids.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-10976410 on NIH RePORTER |
What this research studies
This research focuses on understanding how immune, microbial, and metabolic factors influence Clostridioides difficile infections (CDI) and inflammatory bowel disease (IBD) in children. By examining the interactions between these factors, the study aims to identify why pediatric patients with IBD are at higher risk for CDI and how these infections can complicate their condition. The research employs advanced techniques like 16S gene sequencing to analyze microbial communities and their impact on health outcomes. Ultimately, the goal is to improve diagnosis and treatment strategies for affected children.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years who have been diagnosed with inflammatory bowel disease.
Not a fit: Patients without inflammatory bowel disease or those older than 11 years may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better management and treatment options for children suffering from CDI and IBD.
How similar studies have performed: Previous research has shown promising results in understanding microbial influences on CDI, but this specific focus on pediatric patients with IBD is relatively novel.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Nicholson, Maribeth Ruth — Vanderbilt University Medical Center
- Study coordinator: Nicholson, Maribeth Ruth
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.