Investigating exosomes from neutrophils as a biomarker and treatment target in COPD
Activated Neutrophilic Exosome as Biomarker and Therapeutic Target in COPD
This study is looking at how tiny particles from immune cells might affect lung damage in people with COPD, with the goal of finding new ways to help manage the condition better.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project ID | NIH-10864964 on NIH RePORTER |
What this research studies
This research focuses on chronic obstructive pulmonary disease (COPD), a serious lung condition that causes breathing difficulties. It examines the role of neutrophil-derived exosomes, which are tiny vesicles released by immune cells, in the progression of COPD. The study aims to quantify the presence of these exosomes and their associated enzymes in patients with COPD compared to healthy individuals. By understanding how these exosomes contribute to lung damage, the research seeks to identify new biomarkers and potential therapeutic targets for better management of the disease.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with COPD, as well as healthy controls who are current or former smokers.
Not a fit: Patients with other unrelated respiratory conditions or those who do not have a history of smoking may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and targeted therapies for patients with COPD.
How similar studies have performed: Previous research has shown promise in using exosomes as biomarkers in other diseases, suggesting potential success for this novel approach in COPD.
Where this research is happening
Birmingham, United States
- University of Alabama at Birmingham — Birmingham, United States (Active)
Researchers
- Principal investigator: Russell, Derek — University of Alabama at Birmingham
- Study coordinator: Russell, Derek
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.