Investigating enzymes that modify sugars in bacteria
Biochemical Investigations of Sugar-Modifying Enzymes
This study is looking at how specific enzymes in bacteria change sugar structures that help them survive and avoid our immune system, which could lead to new ways to fight infections.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-10764801 on NIH RePORTER |
What this research studies
This research focuses on understanding how certain enzymes in bacteria modify carbohydrate structures, particularly those found in lipopolysaccharides and capsular polysaccharides. By studying these enzymes, the research aims to uncover their roles in bacterial virulence and how they help bacteria evade the immune system. The approach involves biochemical investigations to analyze the structures and activities of these enzymes, which could lead to new insights into bacterial behavior and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with infections caused by Gram-negative bacteria, such as Campylobacter jejuni.
Not a fit: Patients with infections caused by Gram-positive bacteria or those not affected by bacterial infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for combating bacterial infections by targeting the enzymes that help bacteria evade the immune response.
How similar studies have performed: Other research has shown success in targeting bacterial enzymes for therapeutic purposes, indicating that this approach has potential for meaningful advancements.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Holden, Hazel M. — University of Wisconsin-Madison
- Study coordinator: Holden, Hazel M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.