Investigating environmental factors linked to neurodegenerative diseases
Environmental risk factors linked to TDP-43 proteinopathies
This study is looking at how certain environmental factors might play a role in the development of brain diseases like Alzheimer's and frontotemporal dementia, and it aims to find out which harmful substances could be involved to help create better treatments for those affected.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-11166313 on NIH RePORTER |
What this research studies
This research explores how environmental exposures may contribute to the development of TDP-43 proteinopathies, which are associated with various neurodegenerative diseases like Alzheimer's and frontotemporal dementia. By using advanced microscopy techniques, the team aims to identify specific toxicants that could influence TDP-43 dysfunction. The study will also examine the cellular pathways involved and seek to uncover new risk factors that could lead to better therapeutic strategies for affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults over 21 years old who are at risk for or diagnosed with neurodegenerative conditions linked to TDP-43 pathology.
Not a fit: Patients with neurodegenerative diseases not associated with TDP-43 pathology may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the identification of new environmental risk factors and therapeutic targets for neurodegenerative diseases.
How similar studies have performed: Previous studies have shown promising results in linking environmental factors to neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Cohen, Todd Jonathan — Univ of North Carolina Chapel Hill
- Study coordinator: Cohen, Todd Jonathan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.