Investigating energy production in the brain related to schizophrenia
Translational assessment of brain bioenergetic function in schizophrenia
This study is looking at how the way your brain uses energy changes in people with schizophrenia, and it aims to find out if these changes affect thinking skills, so we can better understand the condition and help those who have it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10741832 on NIH RePORTER |
What this research studies
This research focuses on understanding how energy metabolism in the brain is altered in individuals with schizophrenia. By using advanced imaging techniques and analyzing brain tissue samples, the study aims to identify specific changes in bioenergetic function that may contribute to cognitive impairments associated with the disorder. The researchers will explore the role of lactate, a byproduct of energy metabolism, and its relationship with brain function in patients with schizophrenia. This comprehensive approach combines various methodologies to provide insights into the underlying mechanisms of the illness.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with schizophrenia who are experiencing cognitive difficulties.
Not a fit: Patients with schizophrenia who do not have cognitive impairments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that improve cognitive function in patients with schizophrenia.
How similar studies have performed: Previous research has indicated that alterations in brain energy metabolism are linked to cognitive deficits in schizophrenia, suggesting that this approach may yield valuable insights.
Where this research is happening
Baltimore, United States
- University of Maryland Baltimore — Baltimore, United States (Active)
Researchers
- Principal investigator: Marano, Christopher — University of Maryland Baltimore
- Study coordinator: Marano, Christopher
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.