Investigating energy production in neurons related to Alzheimer's disease
Alterations in somatodendritic bioenergetics in Drosophila models of tauopathy
This study is looking at how brain cells keep their energy up and stay balanced, especially in the context of Alzheimer's disease, using fruit flies to see how different energy-making processes work when neurons are active.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10891789 on NIH RePORTER |
What this research studies
This research focuses on understanding how neurons maintain their energy levels and ionic balance, which is crucial for their function, particularly in the context of Alzheimer's disease and related dementias. The study uses Drosophila models to explore the roles of glycolysis and mitochondrial respiration in producing ATP, the energy currency of cells, during neuronal activity. By imaging live neurons, researchers aim to determine how these energy production pathways are affected in neurodegenerative conditions, potentially revealing new insights into the mechanisms of Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for or diagnosed with Alzheimer's disease or related dementias.
Not a fit: Patients with non-neurodegenerative conditions or those not affected by Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that improve neuronal function and slow the progression of Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding bioenergetics in neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Houston, United States
- University of Texas Hlth Sci Ctr Houston — Houston, United States (Active)
Researchers
- Principal investigator: Venkatachalam, Kartik — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Venkatachalam, Kartik
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.