Investigating early signs of Alzheimer's disease using marmoset models
U19 MARMO-AD Supplement: Resources for Marmoset Fibroblasts Conversion Pipeline
This study is looking at marmoset monkeys to better understand the early changes in the brain that happen with Alzheimer's disease, which could help us find new ways to prevent and treat the condition for people affected by it.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11081122 on NIH RePORTER |
What this research studies
This research focuses on developing marmoset monkeys as a model to study the early cellular and molecular changes associated with Alzheimer's disease (AD). By utilizing a large colony of marmosets, the team will employ advanced imaging and molecular techniques to track the progression of AD from its earliest stages. The research aims to uncover the genetic and biological factors that contribute to AD, which could lead to better prevention and treatment strategies. Patients may benefit from insights gained through this research that could inform future therapies for Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals at risk for Alzheimer's disease or those with early signs of cognitive decline.
Not a fit: Patients with advanced Alzheimer's disease or those not at risk for the condition may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding and treating Alzheimer's disease, potentially improving outcomes for millions affected by this condition.
How similar studies have performed: Previous research using animal models has shown promise in understanding Alzheimer's disease, suggesting that this approach could yield valuable insights.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Silva, Afonso C — University of Pittsburgh at Pittsburgh
- Study coordinator: Silva, Afonso C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.