Investigating early signs of Alzheimer's disease in adults in their sixties
Official title: Lifecourse Predictors and Mechanisms of Early Clinical ADRD among Black and White Adults in their Sixties
Funded at University of California, San Francisco · NIH-11054468 · Data updated 2026-11-12
This study is looking at how early signs of Alzheimer's disease show up in people in their sixties, focusing on things like genetics, heart health, and social connections, to help find ways to prevent and treat the disease better, especially for different groups of people.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $1,279,893 |
| NIH project number | 1R01AG091431-01 |
| Project ID | NIH-11054468 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are Black and White adults in their sixties who are part of the CARDIA study.
✕Less likely to help
Patients outside of the age range or those not participating in the CARDIA study may not benefit from this research.
What this research studies
This research focuses on understanding how early signs of Alzheimer's disease and related disorders develop in adults during their sixties, particularly examining the roles of genetics, cardiovascular health, and social factors. By analyzing data from the Coronary Artery Risk Development in Young Adults (CARDIA) study, researchers will assess cognitive function and brain health in participants as they transition from midlife to late life. The goal is to identify early indicators of Alzheimer's disease to improve prevention and treatment strategies, especially in diverse populations.
Why it matters
Potential benefit: If successful, this research could lead to earlier detection and better prevention strategies for Alzheimer's disease, improving outcomes for patients.
How similar studies have gone: Previous research has shown promise in identifying early indicators of Alzheimer's disease, making this approach both relevant and potentially impactful.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Yaffe, Kristine — University of California, San Francisco
- Study coordinator: Yaffe, Kristine
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.