Investigating early onset Alzheimer's disease and related dementias
Official title: Early Onset Alzheimer's Disease and Related Dementias: A Population-Based Approach to Identify Characteristics and Risk Factors
Funded at University of Minnesota · NIH-11045713 · Data updated 2026-11-12
This study is looking at early onset Alzheimer's disease and related dementias in people under 65 to find out what factors, like heart health and lifestyle choices, might influence when symptoms start, so we can better understand this condition and help those affected.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | June 15, 2023 |
| Project end | February 28, 2027 |
| Funding year | 2025 |
| Award (this year) | $676,246 |
| NIH project number | 5R01AG079108-03 |
| Project ID | NIH-11045713 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or related dementias before the age of 65, as well as those with a family history of these conditions.
✕Less likely to help
Patients diagnosed with Alzheimer's disease after the age of 65 may not receive direct benefits from this research.
What this research studies
This research focuses on understanding early onset Alzheimer's disease and related dementias (EOD), which affects individuals diagnosed before the age of 65. By utilizing data from five large, diverse population-based studies, the research aims to identify characteristics and risk factors associated with EOD. The study will explore the impact of cardiovascular, lifestyle, and behavioral factors on the onset of EOD, as well as how genetic predispositions may influence the age at which symptoms appear. This comprehensive approach seeks to provide a clearer picture of EOD and its underlying causes.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of early onset Alzheimer's disease, potentially enhancing the quality of life for affected individuals.
How similar studies have gone: This research builds on previous studies that have successfully identified risk factors for dementia, but it specifically targets the understudied area of early onset Alzheimer's disease.
Where this research is happening
-
University of Minnesota
Minneapolis, United States Active
Researchers
- Principal investigator: Sedaghat, Sanaz — University of Minnesota
- Study coordinator: Sedaghat, Sanaz
Related research
Other NIH-funded projects on the same topics.
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P-CARRS-BRAIN: Predicting Alzheimer’s risk in South Asians in India using genetics, behavior, and vascular data
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Sleep and body temperature changes linked to Alzheimer’s risk in adults with Down syndrome
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Sex-specific blood biomarkers to predict Alzheimer's and related dementias
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.