Investigating early life factors that influence Alzheimer's disease and related disorders
Building an unbiased pooled cohort for the study of lifecourse social and vascular determinants of Alzheimer's Disease and Related Disorders
This study is looking at how things like social experiences and blood vessel health from childhood to adulthood can affect the chances of developing Alzheimer's and related dementias later in life, so we can find ways to help prevent or delay these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11076673 on NIH RePORTER |
What this research studies
This research aims to understand how social and vascular risk factors for Alzheimer's disease and related dementias (ADRD) develop from childhood through adulthood. By creating a synthetic cohort that combines data from various age groups, the study seeks to evaluate the impact of these early life factors on the risk of developing ADRD later in life. The researchers will address challenges related to participant survival and enrollment to ensure accurate findings. Ultimately, the goal is to identify critical intervention points to prevent or delay the onset of ADRD.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals from diverse age groups, particularly those who are children, young adults, and older adults, as well as those with a family history of Alzheimer's disease.
Not a fit: Patients who are currently diagnosed with advanced Alzheimer's disease or related dementias may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or delaying Alzheimer's disease and related disorders.
How similar studies have performed: Previous research has shown promise in using synthetic cohorts to study complex health outcomes, suggesting that this approach could yield valuable insights into ADRD.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Zeki Al Hazzouri, Adina — Columbia University Health Sciences
- Study coordinator: Zeki Al Hazzouri, Adina
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.