Investigating early events in the lifecycle of flaviviruses like dengue and Zika
Essential early events in the flavivirus lifecycle
This study is looking at how viruses like dengue and Zika get into and multiply in human and mosquito cells, using the yellow fever virus as a model, to find new ways to help develop treatments for these infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11042279 on NIH RePORTER |
What this research studies
This research focuses on understanding the initial stages of flavivirus infections, particularly how these viruses, including dengue and Zika, enter and replicate within human and mosquito cells. The team uses the yellow fever virus as a model to explore the mechanisms that allow the virus to uncoat and begin replication. By identifying key cellular factors involved in these processes, the research aims to uncover potential targets for antiviral therapies. The study employs advanced genetic techniques to manipulate and observe the interactions between the virus and host cells.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals at risk for flavivirus infections, such as those living in endemic areas or travelers to these regions.
Not a fit: Patients who are not at risk for flavivirus infections or those who have already been vaccinated against these viruses may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new antiviral treatments for diseases caused by flaviviruses.
How similar studies have performed: Other research has shown success in targeting early viral lifecycle events, indicating that this approach has potential for significant breakthroughs in antiviral therapy.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Uchil, Pradeep D — Yale University
- Study coordinator: Uchil, Pradeep D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.