Investigating early cognitive symptoms in Alzheimer's disease using imaging and digital tools
Regional tau deposition and digital assessment of cognition in preclinical AD and MCI
This study is looking at how the buildup of tau protein in the brain affects thinking and memory in people who might be at risk for Alzheimer's or mild cognitive issues, and it will involve tests and language analysis to spot early signs of changes in their cognitive health.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-10687981 on NIH RePORTER |
What this research studies
This research focuses on understanding how tau protein deposition in the brain relates to cognitive decline in individuals at risk for Alzheimer's disease and mild cognitive impairment. By integrating advanced imaging techniques and digital assessments, the study aims to identify early signs of cognitive and psychiatric symptoms. Participants will undergo neuropsychological testing and their spoken language will be analyzed to provide insights into their cognitive health. The research will involve large cohorts of individuals with varying levels of amyloid presence, allowing for a comprehensive examination of cognitive decline.
Who could benefit from this research
Good fit: Ideal candidates for this research include older adults who are clinically normal or have mild cognitive impairment, particularly those with varying levels of amyloid presence.
Not a fit: Patients with advanced Alzheimer's disease or those without cognitive concerns may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier detection and better understanding of Alzheimer's disease, potentially improving patient outcomes through timely interventions.
How similar studies have performed: Previous research has shown promise in using imaging and digital biomarkers to assess cognitive decline, indicating that this approach could yield valuable insights.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Young, Christina B — Stanford University
- Study coordinator: Young, Christina B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.