Investigating early changes in kidney cells in diabetic patients
The Single Cell Landscape of Early Human Diabetic Nephropathy
['FUNDING_CAREER'] · UNIVERSITY OF PENNSYLVANIA · NIH-11000338
This study is looking at how diabetes affects the cells in the kidneys, hoping to find clues that could help prevent or treat kidney problems for people with diabetes.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PENNSYLVANIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-11000338 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the early cellular changes that occur in the kidneys of individuals with diabetes. By using advanced techniques like single nucleus RNA sequencing and ATAC sequencing, researchers will analyze kidney samples from both healthy individuals and those with diabetes to identify specific gene expression patterns and chromatin accessibility changes. The goal is to uncover how these changes contribute to diabetic kidney disease, which is a leading cause of kidney failure. The findings may lead to new insights into potential therapeutic targets for preventing or treating kidney damage in diabetic patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who have been diagnosed with diabetes and may be experiencing early signs of kidney disease.
Not a fit: Patients who do not have diabetes or those with advanced kidney disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing or treating kidney disease in diabetic patients.
How similar studies have performed: Previous research using similar sequencing techniques has shown promise in understanding various diseases, suggesting that this approach could yield valuable insights into diabetic kidney disease.
Where this research is happening
PHILADELPHIA, UNITED STATES
- UNIVERSITY OF PENNSYLVANIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WILSON, PARKER C. — UNIVERSITY OF PENNSYLVANIA
- Study coordinator: WILSON, PARKER C.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.