Investigating early changes in brain activity related to Alzheimer's disease
Official title: Electrophysiological and molecular imaging of early AD progression
Funded at University of California, San Francisco · NIH-11167699 · Data updated 2026-11-12
This study is looking at how Alzheimer's disease impacts the brain even before symptoms show up, and it's for people who might be at risk; by using special imaging technology, researchers hope to spot early signs of brain changes that could help find new ways to prevent serious memory problems later on.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | August 15, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $795,943 |
| NIH project number | 5R01AG088398-02 |
| Project ID | NIH-11167699 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates include individuals showing early signs of cognitive decline or those at risk for Alzheimer's disease.
✕Less likely to help
Patients with advanced Alzheimer's disease or those without any cognitive impairment may not benefit from this research.
What this research studies
This research focuses on understanding how Alzheimer's disease affects brain function before noticeable symptoms appear. By using advanced imaging techniques, researchers will monitor changes in neuronal firing patterns in individuals at risk for Alzheimer's. The study aims to identify early signs of neurodegeneration, which could lead to new ways to intervene before significant cognitive decline occurs. Participants will be involved in a longitudinal study that tracks these changes over time.
Why it matters
Potential benefit: If successful, this research could lead to earlier diagnosis and intervention strategies for Alzheimer's disease, potentially slowing its progression.
How similar studies have gone: Other research has shown promise in using electrophysiological techniques to detect early changes in brain activity related to neurodegenerative diseases.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Ranasinghe, Kamalini Gayathree — University of California, San Francisco
- Study coordinator: Ranasinghe, Kamalini Gayathree
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.